Association of vitamin D and vitamin B12 with cognitive impairment in elderly aged 80 years or older:
Publisert feb. 2019
AbstractBackground: The present study aimed to assess the association of vitamin Dand vitamin B12with cognitive impairment in elderly people.Methods: The data were obtained from a cross-sectional study that includedindividuals aged 80 years or older living in the urban and rural areas of thecities of Sideropolis and Treviso in the state of Santa Catarina, Brazil. Intotal, 165 elderly people were included in the analysis. The outcome of cog-nitive decline was assessed by the Mini-Mental State Examination. VitaminD and vitamin B12levels were measured from blood samples. The socio-demographic, anthropometric and health variables used in the analysis werecollected from a questionnaire. Crude and adjusted analyses of the relation-ship between vitamins D and B12and cognitive decline were performedusing a Poisson regression model.Results: The prevalence of cognitive decline was 35.2%. In the adjustedmodel, individuals who had vitamin D levels >19 ng mL1showed a lowerprevalence of cognitive decline (prevalence ratio = 0.59; 95% conﬁdenceinterval = 0.39-0.87). Those participants who had vitamin B12levels of≥496 pg mL1had a higher prevalence of cognitive decline (prevalenceratio = 1.90; 95% conﬁdence interval = 1.08-3.36).Conclusions: The present study showed that individuals aged ≥80 yearswho had vitamin D levels of ≤18 ng mL1had a higher prevalence of cog-nitive decline even after adjustment for potential confounders. In addition,the study demonstrated that vitamin B12levels of ≥496 pg mL1in thispopulation were also a risk factor for cognitive decline. A cross-sectionalanalysis does not enable the inference of a cause-effect relationship andadditional studies are needed to understand these relationship.