Analysis of risk factors for vitamin B12 deficiency in patients with type 2 diabetes mellitus and its relation to the use of metformin
I denne tverrsnittsstudien vurderte forskerne sammenhengen mellom vitamin B12-mangel og risikofaktorer, samt undersøkte sammenhengen mellom etablert mangel og klinisk perifer nevropati.
In this cross-sectional study, researchers assessed the association between vitamin B12 deficiency and its risk factors, as well as examined the connection between established deficiency and clinically detectable peripheral neuropathy. Study participants included patients with type 2 diabetes mellitus who were assisted at a public health care service, which is a reference center in Diabetes. The study covered 316 subjects, 91% of which were users of metformin. In addition to an association with the use of angiotensin-converting enzyme inhibitors, a dose-dependent association between metformin use and vitamin B12 deficiency was found. Peripheral neuropathy in 41% of patients was observed and was not related to vitamin B12 deficiency. Among metformin users, the prevalence of peripheral neuropathy was lower.Les mer her