Analysis of risk factors for vitamin B12 deficiency in patients with type 2 diabetes mellitus and its relation to the use of metformin


 I denne tverrsnittsstudien vurderte forskerne sammenhengen mellom vitamin B12-mangel og risikofaktorer, samt undersøkte sammenhengen mellom etablert mangel og klinisk perifer nevropati. 

In this cross-sectional study, researchers assessed the association between vitamin B12 deficiency and its risk factors, as well as examined the connection between established deficiency and clinically detectable periph­eral neuropathy. Study participants included patients with type 2 diabetes mellitus who were assisted at a public health care service, which is a reference center in Diabetes. The study covered 316 subjects, 91% of which were users of metformin. In addition to an association with the use of angiotensin-converting enzyme inhibitors, a dose-depend­ent association between metformin use and vitamin B12 deficiency was found. Peripheral neuropathy in 41% of patients was observed and was not related to vitamin B12 deficiency. Among metformin users, the prevalence of peripheral neuropathy was lower.

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